Table 1.
Hepatic gene expression for lean (L, n=8), obese (O, n=8) animals and NR obese (NRO, n=9) at 1 year of age.
| Metabolic pathways | mRNA | L | O | NRO | Juvenile-onset obesity | Prenatal restriction |
|---|---|---|---|---|---|---|
| Glucose metabolism | PCK2 | 1.0±0.1 | 2.7±0.9 | 4.4±1.1 | * | NS |
| Glucokinase IV | 1.0±0.4 | 11±3.4 | 30±8.4 | * | NS | |
| Insulin sensitivity and growth | Insulin receptor | 1.0±0.4 | 0.3±0.06 | 0.2±0.1 | * | NS |
| IGF1R | 1.0±0.2 | 0.3±0.05 | 0.6±0.1 | * | NS | |
| IGFBP1 | 1.0±0.3 | 1.1±0.2 | 2.7±0.4 | NS | * | |
| IGFBP3 | 1.0±0.2 | 0.4±0.1 | 0.4±0.1 | * | NS | |
| GH receptor | 1.0±0.2 | 0.4±0.1 | 0.4±0.1 | * | NS | |
| Glucocorticoids and inflammation | Glucocorticoid receptor | 1.0±0.2 | 3.8±1.1 | 2.9±0.5 | † | NS |
| HSD11B1 | 1.0±0.1 | 1.7±0.4 | 4.7±1.1 | NS | * | |
| HSD11B2 | 1.0±0.1 | 2.0±0.2 | 4.6±1.0 | * | * | |
| TNF (α) | 1.0±0.3 | 1.0±0.4 | 1.2±0.5 | NS | NS | |
| IL6 | 1.0±0.2 | 0.5±0.1 | 0.3±0.1 | NS | NS | |
| Lipid metabolism and mitochondrial bioactivity | PRKAA2 | 1.0±0.2 | 2.2±0.8 | 2.6±1.0 | NS | NS |
| PPARA | 1.0±0.3 | 0.2±0.05 | 0.2±0.1 | * | NS | |
| PPARG | 1.0±0.7 | 2.2±0.6 | 6.3±1.2 | NS | † | |
| PGC1 α | 1.0±0.1 | 0.4±0.03 | 6.4±0.1 | † | † | |
| UCP2 | 1.0±0.1 | 3.7±0.2 | 3.9±0.3 | ‡ | NS |
Significant effects of juvenile-onset obesity (i.e L versus O) and prenatal nutrient restriction (O versus NRO) were assessed using Student's unpaired t-test: *P<0.05, †P<0.01, ‡P<0.005.