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DNMT inhibitors and PTEN/PI3K/Akt pathway. PTEN/PI3K/Akt pathway physiologically plays a key role in the control of many processes essential for the cellular life. The tumor suppressor PTEN negatively controls the PI3K/Akt pathway and its epigenetic loss, frequent in cancer cells, leads to the aberrant pathway activation. DNMT inhibitors restore the PTEN expression by epigenetic mechanisms.
