Table 1.
MIC values of host defence peptides against S. aureus and L. monocytogenes wild types and two-component system mutants.
| MIC (μg/ml) | ||||||
|---|---|---|---|---|---|---|
| Strain | Description | Plec | Euro | Prot | NovC | NovS |
| 8325-4 | S. aureus wild type | 16 | 32 | 16 | 1 | 128 |
| 8325-4 hssR::bursa | Transposon mutant | 32 | 64 | 16 | 1 | 128 |
| 8325-4 hssR::bursa/pRMC2-hssRS | Complementation of hssR transposon mutant | 16 | 32 | nd | nd | nd |
| 8325-4 hssR | Transduced 8325-4 hssR mutant | 32 | 64 | 16 | 1 | 128 |
| 15981 | S. aureus wild type | 8 | 8 | 16 | 1 | >128 |
| 15981 ΔTCS15 (hssRS) | hssRS deletion mutant | 32 | 32 | 16 | 1 | >128 |
| LO28 | L. monocytogenes wild type | 64 | 128 | 16 | 1 | 16 |
| LO28 RR23 | rr23 insertion mutant | 64 | 128 | 16 | 1 | 16 |
Plec: plectasin, Euro: eurocin, Prot: protamine, NovC: novicidin, NovS: novispirin. nd: not determined.