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. 2010 Nov 11;3:296. doi: 10.1186/1756-0500-3-296

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Copyright ©2010 Bhavnani et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The Relationship between Gene Degree and the Proportion of Down-Regulated Genes in the Renal Network. The proportion of down-regulated genes is much larger in high degree genes, compared to low degree genes. This pattern is significantly different from that generated from 1000 random networks of the same size and distribution. Two genes of degree 5 have been eliminated from the graph due their low number, making them inappropriate for the statistical comparison. However, as both of degree 5 genes were down-regulated, they follow the overall trend shown.