Table 1.
Individual and median vancomycin pharmacokinetic parameters and body weights
| Patient | Cls (ml/min) | Cld (ml/min) | Vc (L) | Vss (L) | t1/2β(hours) | Body Weight (kg) |
|---|---|---|---|---|---|---|
| 1 | 7.4 | 11.1 | 9.3 | 56.4 | 91.1 | 81 |
| 2 | 10.0 | 23.5 | 11.0 | 77.2 | 90.7 | 101 |
| 3 | 7.9 | 9.8 | 12.2 | 63.5 | 95.4 | 110 |
| 4 | 7.1 | 9.8 | 11.7 | 52.3 | 87.3 | 104 |
| 5 | 5.3 | 7.1 | 8.4 | 34.8 | 78.1 | 59 |
| 6 | 6.9 | 12.9 | 14.8 | 54.4 | 92.4 | 59 |
| Median | 7.2 | 10.4 | 11.3 | 55.4 | 90.9 | 91 |
Cls, systemic clearance; Cld, distribution clearance between the central and peripheral compartments; Vc, apparent volume of distribution in the central compartment; Vss, apparent volume of distribution at steady-state; and t1/2β, terminal elimination half-life (i.e., interdialytic half-life).