Table 3.
Regimen (mg/kg) | First |
Second |
Third |
|||
---|---|---|---|---|---|---|
Cmin48(μg/ml) | AUC0 to 48(μg/h per ml) | Cmin96(μg/ml) | AUC48 to 96(μg/h per ml) | Cmin144(μg/ml) | AUC96 to 144(μg/h per ml) | |
15 LD, 7.5 MD | 8.7 ± 1.4 | 892 ± 182 | 8.9 ± 1.5 | 866 ± 164 | 9.0 ± 1.6 | 873 ± 163 |
15 LD, 15 MD | 8.7 ± 1.4 | 892 ± 182 | 13.2 ± 2.2 | 1310 ± 253 | 15.6 ± 2.7 | 1530 ± 289 |
20 LD, 7.5 MD | 11.7 ± 1.9 | 1190 ± 243 | 10.4 ± 1.8 | 1006 ± 188 | 9.7 ± 1.7 | 945 ± 175 |
20 LD, 10 MD | 11.7 ± 1.9 | 1190 ± 243 | 11.8 ± 2.0 | 1160 ± 218 | 11.9 ± 2.1 | 1160 ± 217 |
Data are means ± SD.