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. 2010 Dec 14;5(12):e14332. doi: 10.1371/journal.pone.0014332

Figure 4. The HAT domain of CBP is required for H4K8ac in the adult Drosophila CNS.

Figure 4

(A) depicts a typical roughened eye phenotype produced when UAS-CBP-FLAD is expressed with the GMR-Gal4 driver during development. (B) displays a wing phenotype with a prominent notch (arrowhead) that is typically observed when UAS-CBP-FLAD is expressed with the c96-Gal4 driver. Both phenotypes are similar to those detected when UAS-CBPi is expressed with the same drivers (Fig. 1). (C) is a control brain (no Gal4; UAS-CBP-FLAD; + heat shocks) stained for H4K8ac, and (D) is an experimental brain (hsGal4; UAS-CBP-FLAD; + heat shocks) stained with the same antibody under the same conditions. Note the dramatic reduction in staining intensity when the HAT-defective form of CBP is expressed.