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. 2010 Dec 14;5(12):e15598. doi: 10.1371/journal.pone.0015598

Figure 3. Differential gene expression at subsequent developmental steps of spermatogenesis.

Figure 3

Chimpanzee and human autosomal and X-linked probes expressed in testis were mapped to mouse probes that show differential expression at subsequent steps of mouse spermatogenesis. The average expression level for autosomal genes (AEL) and that for the X-chromosomal genes (XEL) represent the expression in chimpanzee and human testes for probes that are: a) downregulated in the BS-PS step; b) upregulated in the BS-PS step; c) downregulated in the PS-RS step; d) upregulated in the PS-RS step. Error bars represent SEM, and an asterisk (*) indicates a statistical significance (Wilcoxon rank sum test) between groups. In a): AEL in chimpanzee lower than AEL in human (p-values 2.2e-16); XEL in chimpanzee lower than XEL in human (p-value 5.9e-7); XEL in chimpanzee lower than AEL in chimpanzee (p-value 3.8e-3). In b): AEL in chimpanzee higher than AEL in human (p-value 9.3e-3); XEL in chimpanzee lower than AEL (p-value 4.4e-7); XEL in human lower than AEL (p-value 2.0e-5). In d): XEL in human higher than AEL (p-value 1.6e-3).