Table 1. Prognostic relevance of clinicopathological variables for disease-specific survival in 249 non-gastrointestinal stromal tumor soft-tissue sarcomas (univariate analyses, log rank test).
Characteristics | Patients (n) | Patients (%) | Median survival (months) | 5-Year survival (%) | P |
Age | |||||
≤ 20 years | 20 | 8 | 15 | 40 | 0.126 |
21–60 years | 113 | 45 | 68 | 52 | |
>60 years | 116 | 47 | 30 | 40 | |
Gender | |||||
Male | 110 | 44 | 41 | 46 | 0.390 |
Female | 139 | 56 | 45 | 45 | |
Patient nationality | |||||
Norwegian | 167 | 67 | 63 | 51 | 0.011 |
Russian | 82 | 33 | 22 | 34 | |
Histological entity | |||||
UndifferentiatedPleomorphic sarcoma | 58 | 23 | 54 | 47 | 0.001 |
Leiomyosarcoma | 64 | 26 | 48 | 48 | |
Liposarcoma | 34 | 14 | NR | 67 | |
Fibrosarcoma | 20 | 8 | 44 | 50 | |
Angiosarcoma | 13 | 5 | 10 | 31 | |
Rhabdomyosarcoma | 16 | 6 | 17 | 38 | |
MPNST | 11 | 4 | 49 | 45 | |
Synovial sarcoma | 16 | 6 | 31 | 29 | |
Sarcoma NOS | 17 | 7 | 9 | 18 | |
Tumor localization | |||||
Extremities | 89 | 36 | 100 | 53 | 0.348 |
Trunk | 47 | 29 | 32 | 44 | |
Retroperitoneum | 37 | 25 | 25 | 38 | |
Head/Neck | 18 | 7 | 15 | 41 | |
Visceral | 58 | 23 | 30 | 42 | |
Tumor size | |||||
≤5 cm | 74 | 30 | 127 | 57 | 0.027 |
5–10 cm | 91 | 37 | 44 | 45 | |
>10 cm | 81 | 32 | 28 | 37 | |
Missing | 3 | 1 | |||
Malignancy grade | |||||
1 | 61 | 25 | NR | 74 | <0.001 |
2 | 98 | 39 | 41 | 45 | |
3 | 90 | 36 | 16 | 26 | |
Tumor depth | |||||
Superficial | 17 | 7 | NR | 93 | <0.001 |
Deep | 232 | 93 | 36 | 42 | |
Metastasis at diagnosis | |||||
No | 206 | 83 | 76 | 53 | <0.001 |
Yes | 43 | 17 | 10 | 10 | |
Surgery | |||||
Yes | 228 | 92 | 59 | 50 | <0.001 |
No | 21 | 8 | 5 | 0 | |
Resection margins | |||||
Wide | 108 | 43 | NR | 62 | <0.001 |
Non-wide/no surgery | 141 | 57 | 21 | 33 | |
Chemotherapy | |||||
No | 191 | 77 | 52 | 47 | 0.424 |
Yes | 58 | 23 | 29 | 40 | |
Radiotherapy | |||||
No | 176 | 71 | 48 | 46 | 0.590 |
Yes | 73 | 29 | 38 | 43 |
Abbreviations: NR, not reached; MPNST, malignant peripheral nerve sheath tumor; NOS, not otherwise specified.