Table 2. Death HRs from multivariate Cox regression analysis from two independent datasets.
| Variable | MSK and CAN/DF Dataseta | |
| HR (95% CI) | p-value | |
| Gender | 1.88 (1.11, 3.17) | 0.019 |
| Age at diagnosis | 1.02 (0.99, 1.05) | 0.22 |
| Adjuvant chemotherapy | 2.02 (1.14, 3.59) | 0.016 |
| Adjuvant radiation therapy | 1.48 (0.81, 2.71) | 0.210 |
| Stage | 2.76 (1.56, 4.88) | 0.00046 |
| NR signatureb | 1.98 (1.04, 3.77) | 0.037 |
a
Memorial Sloan-Kettering Cancer Center (MSK) and Dana-Farber Cancer Institute (CAN/DF).
b
The NR signature for the Memorial Sloan-Kettering Cancer Center and Dana-Farber Cancer Institute dataset (n = 186) was derived from the prediction model built from the University of Michigan Cancer Center and Moffitt Cancer Center training dataset.