Figure 6. Lisinopril concentrations effective in protection of endothelial cell layers from damage due to L. interrogans.

Ea.hy926 endothelial cell layers were infected with L. interrogans sv. Copenhageni as described in Materials and Methods, except that just prior to the addition of the bacteria the drugs lisinopril or telmisartan were added to the concentrations indicated. The micrographs were taken at the 3 hour time point. Lisinopril at 10 µM, 1 µM and 100 nM blocked endothelial disruption by L. interrogans; lisinopril at 10 nM or below did not.