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. 2010 Dec 13;191(6):1141–1158. doi: 10.1083/jcb.201007152

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© 2010 Otera et al.

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Figure 9. — Off-target effect of Fis1 RNAi on mitochondrial morphology. (A) Fis1 and Drp1 protein levels in the indicated RNAi cells. (B) Comparison of mitochondrial morphology in WT, Fis1 CKO, and the indicated RNAi cells. Cells were immunostained with anti–cytochrome c antibody. (C and D) Comparison of mitochondrial morphology in lentivirus-infected control RNAi or Fis1 RNAi HeLa (C) or HCT116 (D) cells immunostained with anti-Tom20 antibody. Knockdown level of each Fis1 shRNA was indicated by Western blotting. The insets show magnified images of the squared regions. Bars, 10 µm.