Table 3.
Clinical details and follow-up of patients showing megaloblastosis in Imatinib treated patients with cytopenia (n = 11)
| S.No | Age/sex | Cytopenia | Past drug history | Months of Imatinib | M:E ratio | B12/folate levels | Response to B12/folate |
|---|---|---|---|---|---|---|---|
| 1 | M/35 | Pancytopenia | Nil, alcoholic | 8 m | 1:1.5 | ND | Response+ |
| 2 | F/41 | Bicytopenia | Nil | 9 m | 1:2 | ND | Response+ |
| 3 | F/38 | Bicytopenia | Nil | 13 m | 3:1 | ND | Not treated |
| 4 | M/23 | Bicytopenia | Hydrea | 19 m | 1:3 | ND | Not treated |
| 5 | M/67 | Bicytopenia | Nil | 11 m | 1:1.5 | ND | Not treated |
| 6 | M/40 | Pancytopenia | Hydrea, Interferon | 13 m | 1.5:1 | ND | Response+ |
| 7 | M/35 | Bicytopenia | Nil | 9 m | 1.5:1 | ND | Response + |
| 8 | M/36 | Pancytopenia | Nil | 6 m | 1:1 | ND | Not treated |
| 9 | F/36 | Bicytopenia | Hydrea | 7 m | 1:1 | B12↑,folate N | Treated→AP, expired |
| 10 | M/56 | Pancytopenia | Busulphan | 12 m | 1.5:1 | ND | Response+ |
| 11 | F/46 | Anemia | Hydrea | 11 m | 1.5:1 | ND | Not treated |
m months, M:E myeloid:erythroid ratio, B12 vitamin B12 levels, Response+ good response to therapeutic vitaminB12 and folate supplements, ND vitamin B12 and folate levels not done due to financial constraints,↑=increased levels, N normal levels, AP accelerated phase