Table 2.

Levofloxacin efficacy against inhalational anthrax in rabbits

						After challenge with B. anthracis
Group ID	No. of rabbits	LD50	Treatment	Antigenemia (h)	Bacteremia (h)	First peak levofloxacin concentration (µg/mL)	First trough levofloxacin concentration (µg/mL)	Second peak levofloxacin concentration (µg/mL)	Second trough levofloxacin concentration (µg/mL)	% Survival 28 d after challenge
Vehicle	8 (4 male, 4 female)	143.0 ± 19.3	Saline	23.6 ± 2.1	20.0 ± 2.0	0	0	0	0	0
25-Levofloxacin	8 (5 male, 3 female)	135.5 ± 23.6	Levofloxacin (25 mg/kg)	20.0 ± 1.2	12.03 ± 1.47	0.17 ± 0.046	10.00 ± 2.21	0.15 ± 0.025	87.5
12.5-Levofloxacin	7 (2 male, 5 female)	101.3 ± 20.9	Levofloxacin (12.5 mg/kg)	18.9 ± 1.4	19.1 ± 1.4	ND	0.069 ± 0.018	5.33 ± 1.16	0.079 ± 0.011	71.4

ND, not determined