Table 1.

Table 1 RE-AIM Dimensions, Definitions, and Questions for Assessing Applicability of Clinical Informatics Interventions for New Settings, Populations, and Circumstances

RE-AIM Dimension	Definition	Questions to Ask to Assess Applicability of Findings of Studies with the Goal of Translating Findings into Practice	Additional Questions to Ask to Assess Applicability of Clinical Informatics Intervention Study Findings
Reach (individual level)	Absolute number, proportion, and representativeness of individuals who are willing to participate in a given initiative, intervention, or program	What percentage of the target population came into contact with or began program? Did program reach those most in need? Were participants representative of your practice setting?
Efficacy/effectiveness (individual level)	Impact of an intervention on important outcomes, including potential negative effects, quality of life, and economic outcomes	Did program achieve key targeted outcomes? Did it produce unintended adverse consequences? How did it affect quality of life? What did the program cost as implemented and what would it cost in your setting?	Did the informatics intervention produce unintended positive consequences? How did the informatics intervention affect quality of care?
Adoption (setting and/or organizational level)	Absolute number, proportion, and representativeness of settings and intervention agents (people who deliver the program) who are willing to initiate a program	Did low-resource organizations serving high-risk populations use it? Did program help the organization address its primary mission? Is program consistent with your values and priorities?
Implementation (setting and/or organizational level)	Setting level—intervention agents' fidelity to the various elements of an intervention's protocol, including consistency of delivery as intended and the time and cost of the intervention; individual level—clients' use of the intervention strategies	How many staff members delivered the program? Did different levels of staff implement the program successfully? Were different program components delivered as intended?	What barriers to implementation (predisposing factors at individual, setting/organizational levels) were identified and how were they addressed? What enabling factors (individual, setting/organizational levels) were required to support the informatics intervention?
Maintenance (individual and setting and/or organizational levels)	Setting level—extent to which a program or policy becomes institutionalized or part of the routine organizational practices and policies; individual level—long-term effects of a program on outcomes for 6 or more mo after the most recent intervention contact	Did program produce lasting effects at individual level? Did organizations sustain the program over time? How did the program evolve? Did those persons and settings that showed maintenance include those most in need?	What reinforcing factors (individual, setting/organizational levels) were required to maintain the informatics intervention?

RE-AIM = Reach, Effectiveness, Adoption, Implementation, and Maintenance.