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. 2010 Nov 30;21(11):565–576. doi: 10.1007/s00335-010-9306-2

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© The Author(s) 2010

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Fig. 5 — Scanning electron micrographs showing abnormal hair cell morphology in the cochlea of Casp3 ^mldy /Casp3 ^mldy (n = 3), Casp3 ^mldy /Casp3 ^tm1Flv (n = 2), Casp3 ^tm1Flv/Casp3 ^tm1Flv (n = 2), and +/+ mice (n = 2) aged 2–3 months. Panel (a i) shows a wild-type organ of Corti, and three well-organised rows of outer hair cells (OHC) and one row of inner hair cells (IHC) are visible. Casp3 ^mldy /Casp3 ^mldy (bi), Casp3 ^mldy / Casp3 ^tm1Flv (c i), and Casp3 ^tm1Flv/Casp3 ^tm1Flv (d i) display OHC degeneration and abnormalities of the stereocilia bundles of IHCs and OHCs. Panels (a ii)–(d ii) show higher-magnification images of the IHCs, and panels (a iii)–(d iii) show higher-magnification images of the OHCs. Casp3 ^mldy /+ (n = 3) and Casp3 ^tm1Flv/+ (n = 2) mice were also analysed (data not shown) but showed no differences to wild-type (see “Results”)