Table 3.
List of 70 SNPs in 18 genes validated in coding regions using RNA-Seq and Sanger sequencing
| Gene | BTA | SNP locationa | Allele variation | Frequency |
|---|---|---|---|---|
| ADCY4 (Adenylate cyclase 4) ENSBTAG00000018419 | 10 | 21091039 | A/T | 50/50 |
| 21093914 | A/T | 60/40 | ||
| 21095171 | A/T | 60/40 | ||
| 21096245 | C/G | 60/40 | ||
| 21096645 | T/A | 60/40 | ||
| CISH (Cytokine-inducible SH2-containing protein) ENSBTAG00000022622 | 22 | 50657856 | G/T | 50/50 |
| 50659783 | T/C | 60/40 | ||
| 50659810 | C/T | 60/40 | ||
| DDIT3 (DNA damage-inducible transcript 3) ENSBTAG00000031544 | 5 | 60415461 | C/G | 60/40 |
| 60416148 | G/T | 60/40 | ||
| 60418030 | G/A | 60/40 | ||
| FURIN (Trans Golgi network protease furin) ENSBTAG00000002939 | 21 | 21527200 | C/G | 50/50 |
| 21528000 | A/T | 60/40 | ||
| 21528001 | T/G | 60/40 | ||
| 21528082 | C/T | 50/50 | ||
| 21532215 | C/A | 60/40 | ||
| IGF1R (Insulin-like growth factor 1 receptor) ENSBTAG00000021527 | 21 | 6862322 | T/C | 60/40 |
| 6866036 | T/C | 60/40 | ||
| 6868728 | C/A | 60/40 | ||
| 6869964 | A/C | 50/50 | ||
| IGFBP6 (Insulin-like growth factor-binding protein 6) ENSBTAG00000021467 | 5 | 29836177 | A/T | 50/50 |
| INSIG1 (Insulin-induced gene 1) ENSBTAG00000001592 | 4 | 121362562 | T/A | 60/40 |
| 121363743 | C/A | 60/40 | ||
| 121363744 | T/G | 60/40 | ||
| 121364402 | A/C | 50/50 | ||
| 121364403 | T/C | 70/30 | ||
| 121364574 | T/G | 60/40 | ||
| 121364685 | G/A | 50/50 | ||
| 121364911 | A/G | 60/40 | ||
| 121365407 | G/A | 60/40 | ||
| 121365607 | T/C | 60/40 | ||
| 121365773 | G/A | 60/40 | ||
| 121365941 | G/A | 60/40 | ||
| 121366597 | A/G | 50/50 | ||
| 121369136 | G/A | 60/40 | ||
| 121369282 | A/G | 60/40 | ||
| 121369843 | G/A | 60/40 | ||
| 121370020 | T/A | 60/40 | ||
| 121370021 | T/A | 50/50 | ||
| 121371117 | C/G | 50/50 | ||
| INSIG2 (Insulin-induced gene 2) ENSBTAG00000002112 | 2 | 73130467 | C/T | 50/50 |
| NMI (N-myc (and STAT) interactor) ENSBTAG00000016219 | 2 | 47179315 | C/G | 60/40 |
| PAPPA (Pregnancy-associated plasma protein-A) ENSBTAG00000004010 | 8 | 110792768 | G/A | 60/40 |
| 110968532 | C/T | 60/40 | ||
| SCAP (Sterol regulatory element-binding protein cleavage- activating protein) ENSBTAG00000015782 | 22 | 53546833 | C/T | 50/50 |
| 53549091 | C/G | 50/50 | ||
| 53552713 | A/T | 60/40 | ||
| SOCS5 (Suppressor of cytokine signaling 5) ENSBTAG00000008987 | 11 | 30359073 | T/A | 60/40 |
| 30360874 | T/C | 60/40 | ||
| SREBF1 (Sterol regulatory element binding protein-1) ENSBTAG00000007884 | 19 | 35680267 | G/A | 60/40 |
| 35680574 | A/G | 60/40 | ||
| 35682842 | A/G | 60/40 | ||
| 35683588 | G/C | 60/40 | ||
| 35685082 | A/T | 60/40 | ||
| SRPR (Signal recognition particle receptor subunit alpha) ENSBTAG00000014105 | 29 | 31200612 | A/C | 50/50 |
| STAT1 (Signal transducer and activator of transcription 1) ENSBTAG00000007867 | 2 | 83382392 | A/T | 60/40 |
| STAT3 (Signal transducer and activator of transcription 3) ENSBTAG00000021523 | 19 | 43780445 | A/G | 70/30 |
| 43780740 | C/A | 60/40 | ||
| STAT5A (Signal transducer and activator of transcription 5A) ENSBTAG00000009496 | 19 | 43729581 | C/G | 50/50 |
| 43730210 | G/A | 60/40 | ||
| 43730211 | T/A | 60/40 | ||
| 43741509 | G/A | 60/40 | ||
| 43743914 | C/G | 50/50 | ||
| 43745596 | C/G | 60/40 | ||
| 43748702 | C/G | 70/30 | ||
| STAT5B (Signal transducer and activator of transcription 5B) ENSBTAG00000010125 | 19 | 43655236 | A/C | 50/50 |
| STAT6 (Signal transducer and activator of transcription 6) ENSBTAG00000006335 | 5 | 60837392 | A/G | 60/40 |
| 60837393 | C/T | 50/50 | ||
| 60845709 | G/T | 60/40 | ||
| 60845948 | G/T | 60/40 |
aSNP location is based on the bovine genome assembly Btau4.0