Table 3.
Adjusteda association of PON1 enzyme measurements (per SD increase) in cord and child blood and neurobehavioral development at 2 years of age: CHAMACOS study, Salinas Valley, California, 2000–2003.
| Enzyme | Mean ± SD | Bayley MDI [β (95% CI)] | Bayley PDI [β (95% CI)] | CBCL PDD [OR (95% CI)] |
|---|---|---|---|---|
| Fetal enzymes (n = 265) | ||||
| ARYase | 34.0 ± 16.8 | 0.8 (−0.6 to 2.1) | −0.6 (−1.8 to 0.7) | 0.8 (0.6 to 1.2) |
| POase | 254.3 ± 165.0 | 0.1 (−1.3 to 1.5) | −1.0 (−2.2 to 0.2) | 1.0 (0.7 to 1.4) |
| 2-year-old enzymes (n = 249) | ||||
| ARYase | 87.0 ± 25.1 | 0.4 (−1.0 to 1.8) | 0.1 (−1.2 to 1.3) | 0.6 (0.4 to 0.9)** |
| POase | 665.2 ± 385.8 | −0.2 (−1.6 to 1.3) | −0.5 (−1.7 to 0.8) | 0.8 (0.6 to 1.3) |
| Maternal enzymes during pregnancy (n = 302) | ||||
| ARYase | 133.3 ± 40.9 | 0.7 (−0.7 to 2.1) | 0.4 (−0.8 to 1.7) | 0.7 (0.5 to 1.0)* |
| POase | 958.6 ± 599.3 | −0.1 (−1.4 to 1.2) | 0.0 (−1.2 to 1.2) | 0.6 (0.4 to 1.0)** |
a
Adjusted for prenatal DAPs and age at assessment, sex, parity, breast-feeding duration, HOME score, maternal PPVT, household poverty status, and assay temperature. Bayley MDI and PDI models also included psychometrician and testing location; PDD models also included maternal depression.
*
p < 0.10.
**
p < 0.05.