Table 2.
Gene Ontology Analysis Comparing Variable and Invariant Microsatellites in Coding Exons.
| Gene Ontology Categorya | Number of Genes with Variable Microsatellites in Category | Number of Genes with Variable Microsatellites in at Least One Other Category | Number of Genes with Invariant Microsatellites in Category | Number of Genes with Invariant Microsatellites in at Least One Other Category | Fold Enrichment among Variable Microsatellites | P Value |
| Triplet repeat expansion | 3 | 50 | 16 | 9,890 | 37.09 | 0.0028 |
| DNA-directed RNA polymerase complex (GO:0000428) | 3 | 44 | 17 | 9,118 | 36.57 | 0.0028 |
| DNA-directed RNA polymerase activity (GO:0003899) | 3 | 49 | 24 | 9,323 | 23.78 | 0.0067 |
| Nucleotidyltransferase activity (GO:0016779) | 4 | 49 | 75 | 9,323 | 10.15 | 0.0067 |
| Compositionally biased region: Poly-Gly | 6 | 42 | 155 | 7,461 | 6.88 | 0.0015 |
| Compositionally biased region: Poly-Ser | 7 | 42 | 230 | 7,461 | 5.41 | 0.0015 |
| Compositionally biased region: Poly-Ala | 6 | 42 | 209 | 7,461 | 5.10 | 0.0054 |
| Compositionally biased region: Poly-Glu | 6 | 42 | 220 | 7,461 | 4.84 | 0.0067 |
| Cellular developmental process (GO:0048869) | 14 | 45 | 1256 | 8,567 | 2.12 | 0.0085 |
| Transcription (GO:0006350) | 18 | 45 | 1713 | 8,567 | 2.00 | 0.0033 |
| Developmental process (GO:0032502) | 20 | 45 | 2207 | 8,567 | 1.73 | 0.0088 |
| Gene expression (GO:0010467) | 20 | 45 | 2212 | 8,567 | 1.72 | 0.0090 |
| Binding (GO:0005488) | 47 | 49 | 7656 | 9,323 | 1.17 | 0.0050 |
a
Only one representative of redundant functional categories that included exactly the same genes is listed. Only categories with P < 0.01 are shown. Total number of queried genes with annotation was 61; total number of background genes with annotation was 11,500.