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. 2010 Dec 15;5(12):e14260. doi: 10.1371/journal.pone.0014260

Figure 3. Salicylate results in a decreased ability to blunt the acoustic startle response (ASR) under conditions of gap inhibition.

Figure 3

Performance during ASR testing was recorded before treatment (Baseline), 1 hr following the second day of salicylate administration (Post Treatment 1) and seven hrs following the third day of salicylate administration (Post Treatment 2). Relative to a full startle response (100%), untreated rats detected the gap and prepulse and could suppress the startle reflex across all frequencies (baseline in A). Across all frequencies significant decreases in pASR were observed relative to baseline both one hour following salicylate administration (Post Treatment 1) and seven hours after treatment (Post Treatment 2) (A). When compared to baseline, p = 0.0001 for both Post Treatment 1 and 2 (compare a–b and a–c). Post Treatment 1 and 2 were also significantly different from one another (b–c; p = 0.0004). At 12 kHz the % sound off startle initially changed by 12% (p = 0.05) from Baseline to Post Treatment 1, but was not significantly different from Baseline during Post Treatment 2 testing (B). Differing letters denote significance across time points, p≤0.05 was significant; error bars equal SEM.