Table 5.
Function of target genes of 9 miRNAs.
Gene Ontology (GO) category or pathway | Enrichment P-values | ||||||||
---|---|---|---|---|---|---|---|---|---|
mir-15b | mir-15a | mir-16 | mir-25 | mir-106a | mir-93 | mir-106b | mir-92 | mir-323 | |
Glioma | 1.9E-02 | ||||||||
Regulation of neurotransmitter levels | 1.3E-02 | 1.1E-02 | |||||||
Neurotransmitter transport | 6.8E-03 | 1.5E-02 | 3.3E-02 | 3.9E-02 | |||||
Long-term potentiation | 4.2E-03 | 3.7E-05 | 2.4E-03 | 3.1E-02 | 1.4E-02 | 5.3E-03 | |||
Synaptic transmission | 2.4E-04 | 4.0E-04 | 5.3E-04 | 3.0E-06 | 4.4E-02 | 1.6E-03 | |||
Neurotransmitter secretion | 1.7E-02 | 1.0E-02 | 2.9E-02 | ||||||
Nervous system development | 3.2E-02 | 1.3E-02 | 5.5E-03 | 2.7E-02 | |||||
Central nervous system development | 2.5E-02 | ||||||||
Transmission of nerve impulse | 2.3E-04 | 9.6E-04 | 4.8E-04 | 1.8E-06 | 6.0E-04 | ||||
Regulation of synaptic plasticity | 4.6E-02 | ||||||||
Synaptic vesicle transport | 2.8E-02 | 3.1E-02 | |||||||
Regulation of synapse structure and activity | 4.6E-02 | ||||||||
Neurological system process | 7.1E-03 | 4.3E-03 | 5.1E-03 | 1.5E-04 | 3.1E-03 | ||||
Learning and/or memory | 3.7E-02 | ||||||||
Learning | 4.0E-02 | ||||||||
Neurofilament | 2.1E-02 | ||||||||
Synaptic vesicle | 1.1E-02 | 8.0E-03 | 2.7E-02 | ||||||
Synaptosome | 1.4E-02 | ||||||||
Synaptic vesicle membrane | 3.4E-02 | ||||||||
Neuron projection | 4.5E-02 | ||||||||
Synapse part | 4.7E-05 | 1.5E-02 | 2.5E-03 | 1.6E-02 | 1.2E-02 | ||||
Synapse | 4.9E-03 | 1.5E-02 | 2.1E-02 | 1.1E-07 | 6.2E-03 | 8.4E-04 | 5.3E-03 | 2.3E-04 | |
Axon guidance | 2.1E-02 | ||||||||
Antigen processing and presentation | 4.0E-02 | ||||||||
Ras protein signal transduction | 1.9E-02 | 2.3E-02 | |||||||
Calcium ion transport | 1.8E-03 | 3.6E-04 | 7.8E-03 | 4.2E-02 | |||||
Calcium signaling pathway | 2.7E-04 | 7.5E-06 | 1.7E-03 | 1.7E-02 | 2.0E-04 | 2.2E-05 | |||
Cell communication | 1.9E-02 | 2.2E-02 | 5.6E-03 | 2.3E-03 | 1.8E-02 | 2.6E-02 | 2.5E-02 | ||
Cell-cell signaling | 1.4E-03 | 8.1E-04 | 9.5E-04 | 4.2E-06 | 7.0E-03 | ||||
Wnt signaling pathway | 4.0E-02 | 2.9E-03 | 7.6E-03 | ||||||
MAPK signaling pathway | 1.5E-02 | 8.4E-03 | 3.8E-02 | 2.6E-02 | |||||
GnRH signaling pathway | 1.0E-02 | 8.7E-05 | 6.6E-03 | ||||||
ErbB signaling pathway | 2.2E-02 | 3.0E-02 | |||||||
B cell receptor signaling pathway | 6.3E-03 | ||||||||
VEGF signaling pathway | 8.4E-03 | ||||||||
T cell receptor signaling pathway | 2.1E-02 | ||||||||
Apoptosis | 2.1E-02 |