Table 6.
Genes with somatic mutations regulate both mRNA and miRNA expressions, and formed triangle regulation cycles.
| Mutation | Gene expression | miRNA expression | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Gene | Damage value | P-value for gene expression | Up or down regulated | miRNA | Damage value | P-value for miRNA expression | Up or down regulated |
| RB1 | LAMP2 | 0 | 8.22E-07 | Up | hsa-mir-340 | 0 | 1.16E-06 | Down |
| DST | OTUB1 | 0 | 5.33E-07 | Down | hsa-mir-15b | 45 | 1.30E-06 | Up |
| FN1 | SSR2 | 0 | 3.67E-07 | Up | hsa-mir-125a | 2 | 4.83E-05 | Down |
| FN1 | TDG | 3 | 5.21E-07 | Up | hsa-mir-125a | 2 | 4.83E-05 | Down |
| TP53 | TP53 | 23 | 1.40E-07 | Up | hsa-mir-504 | 1 | 1.42E-06 | Down |
| Mutation-gene regression | miRNA-gene regression | Mutation-miRNA regression | ||||||
| Regression coefficient | P-value | Coefficient of determination | Regression coefficient | P-value | Coefficient of determination | Regression coefficient | P-value | Coefficient of determination |
| 1.03E+00 | 7.04E-04 | 6.47E-02 | -2.77E+02 | 3.17E-06 | 8.50E-02 | 1.81E+00 | 4.10E-09 | 1.85E-01 |
| 1.23E+00 | 5.91E-04 | 6.65E-02 | -2.28E+01 | 9.77E-07 | 9.34E-02 | 1.27E+00 | 3.80E-04 | 7.18E-02 |
| 1.54E+00 | 1.02E-05 | 1.07E-01 | -2.33E+02 | 4.92E-05 | 6.52E-02 | -1.18E+00 | 8.72E-04 | 6.33E-02 |
| 1.39E+00 | 7.60E-05 | 8.72E-02 | -6.91E+01 | 4.77E-05 | 6.54E-02 | -1.18E+00 | 8.72E-04 | 6.33E-02 |
| 2.81E-01 | 3.30E-02 | 2.62E-02 | -4.14E+01 | 2.72E-06 | 8.61E-02 | 3.43E-01 | 9.10E-03 | 3.93E-02 |