Table 6.
Multiple regression analyses predicting a) basic cognition/fine motor functions, b) cognitive performance, c) global functioning
| total | male | female | |||||||
|---|---|---|---|---|---|---|---|---|---|
| β | t | p | β | t | p | β | t | p | |
| a) basic cognition/fine motor functions1 | |||||||||
| duration of disease (years) | -.346 | -11.92 | < .001 | -.353 | -9.68 | < .001 | -.318 | -6.59 | < .001 |
| positive symptoms (PANSS) | -.006 | -0.18 | .856 | -.028 | -0.69 | .489 | .065 | 1.08 | .283 |
| negative symptoms (PANSS) | -.334 | -10.05 | < .001 | -.293 | -7.32 | < .001 | -.415 | -7.01 | < .001 |
| catatonic signs (CNI) | -.126 | -4.26 | < .001 | -.128 | -3.45 | .001 | -.161 | -3.27 | .001 |
| medication (CPZ-equivalents) | -.080 | -2.70 | .007 | -.066 | -1.83 | .068 | -.147 | -2.84 | .005 |
| regression model |
r2 = .324 p < .001 |
r2 = .306 p < .001 |
r2 = .383 p < .001 |
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| b) cognitive performance2 | |||||||||
| duration of disease (years) | -.335 | -11.54 | < .001 | -.356 | -9.72 | < .001 | -.294 | -6.12 | < .001 |
| positive symptoms (PANSS) | -.015 | -0.44 | .658 | -.033 | -0.80 | .427 | .023 | 0.38 | .704 |
| negative symptoms (PANSS) | -.351 | -10.47 | < .001 | -.320 | -7.92 | < .001 | -.396 | -6.56 | < .001 |
| catatonic signs (CNI) | -.132 | -4.46 | < .001 | -.103 | -2.76 | .006 | -.204 | -4.16 | < .001 |
| medication (CPZ-equivalents) | -.082 | -2.74 | .006 | -.060 | -1.62 | .105 | -.140 | -2.70 | .007 |
| regression model |
r2 = .330 p < .001 |
r2 = .305 p < .001 |
r2 = .394 p < .001 |
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| c) global functioning3 | |||||||||
| duration of disease (years) | -.028 | -1.29 | .198 | -.008 | -0.28 | .780 | -.062 | -1.78 | .076 |
| positive symptoms (PANSS) | -.441 | -17.33 | < .001 | -.458 | -14.45 | < .001 | -.415 | -9.60 | < .001 |
| negative symptoms (PANSS) | -.380 | -15.02 | < .001 | -.345 | -10.97 | < .001 | -.430 | -10.0 | < .001 |
| catatonic signs (CNI) | -.060 | -2.67 | .008 | -.050 | -1.71 | .088 | -.093 | -2.58 | .011 |
| medication (CPZ-equivalents) | -.106 | -4.71 | < .001 | -.122 | -4.29 | < .001 | -.078 | -2.07 | .040 |
| regression model |
r2 = .596 p < .001 |
r2 = .559 p < .001 |
r2 = .662 p < .001 |
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1A basic cognition/fine motor composite score was used as a dependent variable comprising alertness (TAP), tapping, and dotting (Chronbachs alpha = .801).
2A cognitive composite score was used as a dependent variable consisting of reasoning (LPS3), 2 processing speed measures (TMT -A and digit-symbol test, ZST), executive functions (TMT-B), working memory (BZT), verbal memory (VLMT) and divided attention (TAP) (Chronbachs alpha = .869).
3Global assessment of functioning (GAF) was used as a dependent variable.