Table 1.
Results of direct sequencing of SOSTDC1
| Sample | Location | Informative SNPs without LOH |
Normal | Tumor |
|---|---|---|---|---|
| RCC-129 | End of Exon 1: rs35324397 |
Yes | A/G | G |
| RCC-614 | Beginning of Exon 1: 16,536,670; 16,536,667 between rs10240242 and rs35324397 |
Yes | G/T, A/G | T, A |
| RCC-614 | Beginning of Exon 1: 16,536,641 between rs10240242 and rs35324397 |
Yes | C/G | C |
| RCC-614 | End of Exon 1: rs35324397 |
Yes | C/G | C |
| RCC-614 | End of Exon 1: 5 bp downstream of rs35324397 |
Yes | A/G | G |
| RCC-635 | Beginning of Exon 1: 16,536,641 between rs10240242 and rs35324397 |
Yes | C/G | C |
| RCC-737 | Exon 5: 16,468,252 closest to rs6959246 |
Yes | G/T | T |
| W-733 | Before Exon 1: rs7781903 |
No | C/T | C |
| W-733 | Beginning of Exon 1: between rs10240242 and rs35324397 |
No | C/G | G |
| W-733 | Beginning of Exon 2: rs7801569 |
No | C/T | C |
| W-8188 | Beginning of Exon 2: rs7801569 |
No | C/T | C |
| W-8197 | Exon 5: 16,468,252 closest to rs6959246 |
No | G/T | T |
SNPs found in the direct sequences are summarized here. All other samples sequenced showed no LOH or other mutations. SNP location relative to sequenced exons and chromosome 7 base pair location is provided. The existence of heterozygous SNPs (informative, but with no LOH present) in the sample is shown via yes/no designation. RCC = adult renal carcinoma samples, W = pediatric Wilms tumors.