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Intracellular Zinc Levels Fall During Dendritic Cell Maturation. After the detection of LPS (Pathogen Associated PAMPs) by TLR4 and activation of TRIF, zinc importers (ZIPs) expression is diminished while transporters (ZNTs) expression is increased. The resulting decrease in intracellular zinc concentration promotes the surface expression of MHC-II and thus the maturation of DCs.
