Calcineurin |
Zinc inhibits Calcineurin activity in Jurkat cells |
[177] |
|
COX-2 |
Lung zinc exposure increases COX-2 |
[178] |
|
Caspases |
Cytosolic caspase-3 activity is increased in Zn-deficient cells. May be mediated by the cytoprotectant abilities of zinc |
[110] |
|
E-selectin |
Zinc deficiency increased E-selectin gene expression |
[179] |
|
FC epsilon RI |
Mast cell activation downstream of FC epsilon requires zinc |
[72,180] |
|
HMGB1 |
3 Cys, 2 His, unknown role of zinc |
[174] |
|
HSP70 |
Zinc increased basal/stress-induced Hsp70 in CD3+ lymphocytes |
[181] |
|
IFN-γ |
ZIP8 influences INF-gamma in T cells |
[177] |
|
IL-1 β |
Zinc suppresses IL-1 beta expression in monocytes |
[39,182] |
|
IL-2 |
High zinc decreased IL-2 in T cell line, Jurkat cells |
[183,184] |
|
IL-2R α |
High zinc decreased IL-2R α in T Cell Line |
[184] |
|
IL-6 |
Zinc modulated circulating cytokine in elderly patients |
[61,185,186] |
|
KIR |
Zinc is necessary for the inhibitory function of KIRs |
[187,188] |
|
MCP-1 |
Zinc modulated circulating MCP-1 in elderly patients |
[185] |
|
MHC Class II |
There is zinc dependent binding site where super-antigens and peptides bind |
[189,190] |
|
NFkB |
NFkB p65 DNA-binding activity increased by zinc deficiency (sepsis). Zinc regulates NFkB. High zinc decreases NFkB activation in T Cell Line. Zinc activates NFkB in T cell line. IKK gamma zinc finger, can regulate NFkB |
[42,179,191,192] |
|
PDE-1,3,4 |
Zinc reversibly inhibited enzyme activity of phosphodiesterases. |
[39] |
|
PPAR-α |
Zinc deficiency down-regulated PPAR-α |
[184] |
|
Proteasome |
Zinc can inhibit proteasome |
[193] |
|
S100 Proteins |
RAGE ligands |
[173] |
|
TLR-2 |
Zinc limits TLR surface expression |
[194] |
|
TNF-α |
Zinc suppresses TNF-α expression in T-Cells, monocytes |
[39,40,184] |
|
Zinc finger proteins |
|
|
A20 zinc finger |
Modulates TLR-4 signaling, Inhibits TNF-induced apoptosis |
[192,195] |
|
DPZF |
BCL-6 Like Zinc Finger, Immune responses |
[196] |
|
Gfi1 |
Antagonizes NFkB p65, Upstream of TNF |
[197,198] |
|
IKK γ |
Zinc finger that regulates NFkB |
[199] |
|
PLZF |
Expressed in iNKT cells. iNKT cells lacking PLZF lack innate cytotoxicity and do not secrete IL-4 or IFN-γ |
[68] |
|
ZAS3 |
Zinc Finger protein that inhibits NFkB |
[200] |