Table 4.
Zinc Transporters (Importers) and Cancer
| Cancer | Transporter | Comment | References |
|---|---|---|---|
| Erythroleukemia | ZIP1 | In the vesicular compartment and partly in the ER in adherent cells | [99] |
| Squamous cell carcinoma | ZIP2 | mRNA is induced by contact inhibition and serum starvation | [202] |
| Prostate | ZIP1, ZIP2, ZIP3 | Down-regulated in malignant cells | [203] |
| Pancreas | ZIP4 | Over-expression is linked to increased cell proliferation | [106] |
| Breast | ZIP6, ZIP10 | Expression is linked to metastasis to lymph node | [204,205] |
| Tamoxifen resistant breast cancer | ZIP7 | Increased levels results in increased growth and invasion | [182,206,207] |