Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed scheme of the synaptic consequences of NMDA-R-Ab. The antibodies block the NR1/NR2 heteromers of the NMDA receptor, causing a state of imbalance between NMDA and AMPA receptors. Blockade of NMDA-R impairs AMPA-R endocytosis. NMDA-R-Ab cause an increased release of glutamate which is dependent on the alpha2-delta subunit of VGCC and which is also related to a deregulation of gabaergic interneurons. NO acts as a retrograde messenger and amplifies glutamate release.
