Table 1.
Sites of injection for the experiments carried out
| Experiment | Site of injection | Working hypothesis |
|---|---|---|
| Dose-response studya,b,c | CA1 rFr2 | NMDA-R Ab impair the glutamate concentrations in the extra-cellular space |
| NMDA and AMPA regulationa,b,c,d | CA1 | NMDA-R Ab impair the NMDA- and AMPA-mediated regulation of glutamate |
| Inhibition of glial transporta,b | CA1 | NMDA-R Ab impair the glial transport of glutamate |
| Blockade of GABA-A receptorsa,b | CA1 | Bicuculline enhances the concentrations of glutamate in case of pre-treatment with NMDA-R Ab |
| Infusion of GABAc | rFr2 | Infusion of GABA decreases the concentrations of glutamate after administration of pregabalin |
| Effects on concentrations of nitric oxide (NO)a,b | rFr2 | NMDA-R Ab increase the concentrations of NO |
aUse of controls' CSF; bUse of patients' CSF; cUse of purified IgG from a patient positive for NMDA-R antibodies; dUse of purified IgGs from a patient positive for anti-Yo antibodies.