Table 1.
Correlation coefficient between gene expression and shikonins content in arnebia.
| Name of the gene | Gene expression in cell culture treated with mevinolin | Gene expression in HSPS |
|---|---|---|
| MVA pathway | ||
| AeACTH | 0.87 | 0.31 |
| AeHMGS | 0.77 | 0.48 |
| AeHMGR | 0.71 | 0.95 |
| AeMVK | 0.62 | 0.44 |
| AePMVK | 0.89 | 0.28 |
| AeMVDD | 0.82 | 0.20 |
| AeIPPI | 0.83 | 0.04 |
| AeGDPS | 0.83 | 0.39 |
| PP pathway | ||
| AePAL | 0.83 | 0.57 |
| AeC4H | 0.68 | 0.59 |
| Ae4-CL | 0.73 | 0.50 |
| Gene for coupling of MVA and PP pathways | ||
| AePGT | 0.88 | 0.91 |
Correlation coefficient was calculated using integrated density value (IDV) of gene expression and the shikonins content in response to the inhibitor (Figure 2) and HSPS (Figure 3), separately. IDV is mentioned in Additional file 7: Supplementary Figure S5 and Additional file 8: Supplementary Figure S6. For Figure 3 linear portion of increase in shikonins content, i.e. day 2, day 4, day 6 and day 8, were considered and accordingly the IDV of gene expression