Table 2.
BED comparison between standard and explored RT schedule
| RT schedule | BED tumor control α/β4 | BED acute effects α/β10 | BED fibrosis α/β1.7 | BED vascular damage α/β2.5 | ||||
|---|---|---|---|---|---|---|---|---|
| W.B. = whole breast B.S. = tumor bed side |
W.B. | B.S. | W.B. | B.S. | W.B. | B.S. | W.B. | B.S. |
|
60 Gy/30 F/6 W (50 Gy + 10 Gy seq.boost) |
75 | 90 | 60 | 72 | 109 | 131 | 90 | 108 |
|
50 Gy/25 F/5 W (no boost) |
75 | 75 | 60 | 60 | 109 | 109 | 90 | 90 |
|
42 Gy/13 F/3W + 1 day (39 Gy + 3 Gy cc.boost) |
68 | 77 | 51 | 56 | 108 | 123 | 86 | 97 |
|
52 Gy/20/F/5 W (46 Gy + 6 Gy cc.boost) |
72 | 87 | 57 | 66 | 108 | 135 | 88 | 108 |
|
UK START TRIAL A 41.6 Gy/13 F/5 W |
75 | 75 | 55 | 55 | 120 | 120 | 95 | 95 |
|
UK START TRIAL A 39 Gy/13 F/5W |
68 | 68 | 51 | 51 | 108 | 108 | 86 | 86 |
boost = concomitant boost; seq.boost = sequential boost; F = fractions; W = weeks