Table 1.
Patient characteristics of the immunohistochemical samples
| Non-smokers n = 16 | Smokers n = 20 | COPD stage I-II n = 20 | COPD stage IV n = 8 | p-value | |
|---|---|---|---|---|---|
| Age, years | 65 (13)** | 63 (8) | 65 (7) | 54 (8) | 0.039 |
| Sex M:F | 8:8 | 15:5 | 16:4 | 5:3 | 0.096 |
| Pack-years | 0* | 46 (20) | 39 (14) | 34 (18) | < 0.001 |
| FEV1 l/s | 2.96 (1.19)§ | 3.02 (0.71) | 2.2 (0.54) | 0.66 (0.24) | < 0.001 |
| FEV1 %predicted | 98 (15) | 91 (9)# | 68 (13) | 21 (12) | < 0.001 |
| FEV1 postbd | 2.98 (1.1) | 3.26 (0.81) | 2.23 (0.38) | NA | |
| FVC | 3.44 (1.3) | 3.59 (0.91) | 3.51 (1.1) | 1.78 (1.0) | < 0.001 |
| FVC postbd | 3.46 (1.21) | 3.79 (1.1) | 3.66 (1.16) | NA | |
| FEV1/FVC % | 86 (9)* | 84 (11)# | 60 (8) | 37 (13) | < 0.001 |
| DCO %predicted | 91 (15)** | 77 (15)§§ | 75 (10) | 29 (8) | < 0.001 |
| DCO/VA %predicted | 89 (11)** | 82 (12)§§ | 77 (21) | 46 (11) | < 0.001 |
Mean (SD)
*The mean difference between non-smokers and smokers is significant at the 0.05 level, Dunnett t-test.
§ The mean difference between non-smokers and COPD-patients is significant at the 0.05 level, Dunnett t-test.
# The mean difference between smokers and COPD-patients is significant at the 0.05 level, Dunnett t-test.
** The mean difference between non-smokers and patients with severe COPD (GOLD stage IV) is significant at the 0.05 level, Dunnett t-test
§§ The mean difference between smokers and patients with severe COPD (GOLD stage IV) is significant at the 0.05 level, Dunnett t-test