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Core mechanism of the Swe1p-dependent G2/M checkpoint in S. cerevisiae. Mitotic progression requires degradation of Swe1p kinase. Failure to degrade Swe1p kinase results in an inhibitory phosphorylation of the cyclin-dependent kinase Cdc28p and activation of the Swe1p-dependent G2/M checkpoint, delaying mitosis. See Introduction for a full description of the checkpoint mechanism.
