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Box 5. Summary of IV PPI use in gastroesophageal reflux disease.
| • IV and oral PPI appear to be equally efficacious in suppressing gastric acid. |
| • IV PPI is useful in patients who have severe erosive esophagitis and are unable to tolerate oral therapy. |
| • Infusional IV PPI can heal erosive esophagitis in a matter of days. Its clinical benefit over IV bolus PPI remains unknown. |
IV, intravenous; PPIs, proton-pump inhibitors.
