• IV PPI has been associated with the development of nosocomial pneumonia in critically ill patients. |
• PPI has also been linked to the development of SBP in cirrhotics. |
• IV PPI in these patients should be used judiciously, and their indications frequently reviewed, as PPI is therapy is often inappropriately continued. |
IV, intravenous; PPIs, proton-pump inhibitors; SBP, spontaneous bacterial peritonitis