Table 1.

Potential treatments and their targets.

Target	Treatment
Obesity	Weight loss
	- Diet with or without exercise
	- Pharmacologic
	• Orlistat
	• Sibutramine
	- Surgical treatment of obesity
Insulin resistance	Insulin sensitizing agents
	- Thiazolidinediones (TZDs)
	- Metformin
	- Meglitinides
Dyslipidemia	Lipid lowering agents
	- Statins
	- Fibrates
	- Omega-3 fatty acids
Oxidative stress	Antioxidants
	- Vitamin E
	- Other vitamins
	- Betaine
	- N-Acetyl-cysteine
	- Lecithin
	- Silymarin
	- Beta-carotene
Pro-inflammatory cytokines	Anti-tumor necrosis factor agents
	- Pentoxifylline
Bacterial overgrowth	Probiotics
	- VSL#3
Apoptosis	Cytoprotective agents
	- Ursodeoxycholic acid (UDCA)
	Novel treatments
	- ACE inhibitors/ARBs
	- Oligofructose
	- Incretin analogs

ACE, angiotensin-converting enzyme; ARBs, angiotensin receptor blockers