Tab. 2.
Composition of different furosemide liquisolid formulations prepared using different liquid vehicles according to theoretical model by Spireas and Bolton [4].
| Batch codea | Drug:liquid vehicle ratio | W (mg) | Lf | Avicel® PH 101 (mg) (Q=W/Lf) | Fumed silica (mg) (q=Q/R) | Potato starch (mg) | Unite dose weight (mg) |
|---|---|---|---|---|---|---|---|
| LS-1 | 1:2 | 60 | 0.274 | 218.98 | 10.95 | 14.50 | 304.40 |
| LS-2 | 1:4 | 100 | 0.274 | 364.96 | 18.25 | 24.16 | 507.40 |
| LS-3 | 1:2 | 60 | 0.168 | 357.10 | 17.86 | 21.75 | 456.71 |
| LS-4 | 1:4 | 100 | 0.168 | 595.20 | 29.76 | 36.25 | 761.21 |
| LS-5 | 1:2 | 60 | 0.837 | 71.64 | 3.51 | 6.76 | 141.91 |
| LS-6 | 1:4 | 100 | 0.837 | 119.40 | 5.90 | 11.27 | 236.57 |
W … weight of liquid medication (drug + liquid vehicle); Lf … liquid load factor; Q … weight of carrier material; q … weight of coating material; R … carrier:coat ratio which equals to 20:1.
a
for the composition of each formula refer to Table 1.