Tab. 4.
The total amount of drug released after 10 minutes (DR10min) and the time necessary to release 50% of the drug from different formulations at different dissolution media.
| Formula Codea | 0.1N HCl (pH1.2) | Distilled water (pH 6.4–6.6) | ||
|---|---|---|---|---|
| DR10min (% ±SD) | T50% (min ±SD) | DR10min (%±SD) | T50% (min ±SD) | |
| DCT | 24 (±2.1) | >60 | 57 (±3.2) | 10 (±1.2) |
| LS-1 | 34 (±3.1) | 50 (±3.5) | 52 (±3.6) | 8.0 (±1.4) |
| LS-2 | 40 (±1.9) | 20 (±2.8) | 64 (±2.7) | 6.0 (±1.3) |
| LS-3 | 0.9 (±0.51) | >60 | 1.3 (±0.71) | >60 |
| LS-4 | 2.2 (±0.92) | >60 | 2.9 (±1.1) | 59 (±4.8) |
a
for the composition of each formula refer to Table 1.