Tab. 2.

Relative Retention time (RRT), Limit of Quantification (LOQ), Relative response factor (RRF) and Recovery data of the Docetaxel and its Impurities.

Name of the Impurity	∼RRT	K1	LOD (in %)	LOQ (in %)	RRF	% RSD at LOQa	%Recovery at LOQb
10-Deacetylbaccatin III	0.11	4.2	0.002	0.006	1.53	2.1	99.0
7-Epi-10-deacetyl-baccatin III	0.20	8.3	NA	NA	NA	NA	NA
7-Epi-10-oxo-10-deacetylbaccatin III	0.22	9.2	NA	NA	NA	NA	NA
2′,3′-Epidocetaxel	0.88	39.9	0.003	0.008	0.96	1.9	106.4
2′-Epidocetaxel	0.94	42.7	0.003	0.009	1.02	3.4	96.4
Oxetane ring opened impurity of Docetaxel	0.97	44.1	0.004	0.011	0.73	2.5	94.7
Docetaxel	1.00	45.4	0.003	0.008	1.00	1.5	100.6
10-Oxodocetaxel	1.05	47.8	0.003	0.014	0.91	3.7	108.3
7′-Epidocetaxel	1.11	50.6	0.003	0.011	1.00	2.4	96.1
10-Oxo-7′epidocetaxel	1.14	52.0	0.002	0.006	1.35	2.6	97.1

NE = Not Established due to non-availability of impurity standards; NA= Not applicable;

^aMean for six determinations;

^bMean for three determinations