Table 1.

Pharmacokinetic parameters of diclofenac in beagle dogs (mean ± SD) following oral administration of 50 mg diclofenac potassium tablet alone (control) or with 100 mg of itraconazole capsule (n=5). *P < 0.05.

Pharmacokinetic Parameter	Diclofenac Alone (control)	Diclofenac with Itraconazole
Cmax (μg/ml)	6.28 ± 3.46	3.65 ± 2.22*
tmax (h)	1.15 ± 0.60	1.94 ± 1.23
AUC0–∞ (μg.h/ml)	25.43 ± 6.18	17.65 ± 5.09*
t1/2 (h)	2.10 ± 0.37	1.98 ± 0.07