Tab. 2.
Statistical comparison of various pharmacokinetic parameters of ETD, SD, KD1(mean± S.D)a
| Subject | Tmax (h) | Cmax (ng/ml) | AUCt (ng×h/ml) | AUC∞ (ng×h/ml) | Ka (h−1) | Kel (h−1) | T½ (h) |
|---|---|---|---|---|---|---|---|
| Etodolac | 3.0 ± 0.0 | 2.795 ± 0.35 | 17.383 ± 1.22 | 17.936 ± 1.20 | 0.309 ± 0.028 | 0.148 ± 0.011 | 4.41 ± 0.85 |
| SD | 3.0 ± 0.0 | 7.014 ± 2.97* | 31.099 ± 6.93* | 44.971 ± 4.54* | 0.379 ± 0.020* | 0.035 ± 0.009* | 20.768 ± 4.87* |
| KD1 | 3.0 ± 0.0 | 4.866 ± 0.07* | 43.846 ± 6.5* # | 45.537 ± 4.94* | 0.441 ± 0.167 | 0.152 ± 0.04*# | 8.34 ± 6.90*# |
a
Data represent mean ± S.D. (standard deviation);
*
Significantly different from group I at 95% level determined by applying one-way ANOVA followed by Tukey’s studentized t-test;
#
Significantly different from group SD at 95% level determined by applying one way ANOVA followed by Tukey’s studentized t-test.