Fig. 1.

(A) Self-reported positive affect following the psychosocial stressor in substance-dependent individuals. Participants who received the placebo transdermal patch reported greater positive affect at the +10 and +20 min time points than either group that received nicotine (P < 0.049). (B) Self-reported negative affect following the psychosocial stressor in substance-dependent individuals. Participants who received the low dose of the transdermal nicotine patch reported greater negative affect at the +20 min time point than all other transdermal groups (P < 0.05).