Table 2. χ2-association tests for common variants identified within PARK16 locus performed by Haploview software.
| Gene | Chr | Mutation | Position (bp) | Associated allele | χ2 | P-value | Case/control frequencies |
|---|---|---|---|---|---|---|---|
| RAB7L1 | 1 | rs708725 | 204 010 761 | A | 0.609 | 0.4351 | 0.443, 0.418 |
| RAB7L1 | 1 | c.197-49insG | 204 007 453 | Ins G | 0.949 | 0.3301 | 0.072, 0.057 |
| RAB7L1 | 1 | rs41302139 | 204 007 291 | C | 0.075 | 0.7844 | 0.019, 0.017 |
| RAB7L1 | 1 | c.379-12insT | 204 006 575 | Ins T | 4.573 | 0.0325 (0.0399) | 0.013, 0.004 |
| SLC41A1 | 1 | rs708727 | 204 034 508 | T | 0.776 | 0.3783 | 0.438, 0.409 |
| SLC41A1 | 1 | rs41264905 | 204 034 656 | T | 1.402 | 0.2364 | 0.009, 0.003 |
| SLC41A1 | 1 | rs11240569 | 204 045 854 | T | 0.971 | 0.3243 | 0.301, 0.270 |
The only variant (c.379-12insT) that showed association with the disease is highlighted in bold; the 1 × 106 permutation value associated to this variant is also shown within parentheses. The case/control frequencies for each variant are also shown.