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. 2010 Aug 30;89(1):214–224. doi: 10.1093/cvr/cvq275

Figure 3.

Figure 3

Effects of LY83583 on relationship between constriction and [Ca2+]i with U46619 pre-constriction. Example traces: Simultaneous measurement of tension (mN) and [Ca2+]i (R340/380) in PA (A) and MA (B). Following pre-constriction with 100 nmol/L U46619 and 1 mmol/L l-NAME, LY83583 was added cumulatively at 10 min intervals, as indicated. Note: constriction and [Ca2+]i responses returned to the pre-constriction level when LY83583 was washed out in the continued presence of U46619/l-NAME. Summary charts: effects of LY83583 on [Ca2+]i (open symbols) and constriction (closed symbols), normalized to responses induced by 80 mmol/L K+, in PA (A, n = 4–5) and MA (B, n = 4). Note: charts do not show effects of washout. Asterisk denotes significant enhancement or reduction of tension or [Ca2+]i compared with the zero time-point (P < 0.05).