Figure 1.

Diabetes promotes remodeling of cerebral vessels. (A) Representative images of the pial vessels after PU4ii injection to visualize middle, anterior, and posterior cerebral arteries trees in control (C), diabetes (D), diabetes+metformin (D+Me), control+minocycline (C+M), or diabetes+minocycline (D+M) groups. Tortuosity index (B), number of collaterals (C), number of anastomoses (D), and collateral diameter (E) were significantly higher in diabetes all of which were prevented by metformin or minocycline treatments. Mean±s.e.m., n=7 to 14, ^*P<0.0001 versus C, ^**P<0.001 versus D, ^***P<0.0002 versus C.