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Diabetes increases myogenic tone of isolated middle cerebral arteries (MCAs). (A) The MCA myogenic tone was increased in diabetic animals and both metformin and minocycline reduced the tone. (B) There was a disease and treatment interaction such that minocycline decreased stiffness in controls but increased it in diabetic rats. Mean±s.e.m., n=7 to 14, *P<0.05 versus C, **P=0.011 versus D, ***P=0.0046 versus C; ****P<0.0001. C, control; D, diabetes.
