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Distribution of AA mutations in Rta functional domains
| Functional domains | residues | EBVaGC(n = 34) | NPC(n = 57) | TWs(n = 28) |
|---|---|---|---|---|
| DNA binding | 273(R-M) | 17(50%) | 38(66.7%) | 9(32.1%) |
| 316(K-E) | 18(52.9%) | 38(66.7%) | 9(32.1%) | |
| Transactivation | 377(A-E) | 11(32.3%) | 20(35.1%) | 18(64.3%) |
| 489(Q-K) | 10(29.4%) | 11(19.3%) | 9(32.1%) | |
| 489(Q-R) | 16(47.1%) | 25(43.9%) | 15(53.6%) | |
| 542(S-N) | 21(61.8%) | 50(87.7%) | 28(100%) |
