Table 1. Characteristics of patients with and without MODS at days 1 and 3 of severe sepsis.
| Day 1 | Day 3 | |||||
| Variables | MODS | Without MODS | p value | MODS | Without MODS | p value |
| n = 38 | n = 29 | n = 29 | n = 29 | |||
| Age (years) | 70 (50–80) | 70 (54–77) | NS | 68 (54–77) | 70 (54–77) | NS |
| Male gender | 31 (81.6) | 19 (65.5) | NS | 23 (74.2) | 19 (65.5) | NS |
| APACHE II score | 27 (24–32) | 21 (18–26) | 0.0008 | 24 (20–31) | 19 (15–22) | 0.01 |
| Body mass index (kg/m2) | 19.9 (18.2–24.9) | 22.5 (18.9–27.4) | 0.01 | 20.1 (18.5–23.8) | 22.5 (18.9–27.4) | NS |
| Prior 24 hrs fluid balance (L) | 3.1 (1.9–4.0) | 2.5 (1.1–3.2) | 0.0008 | 1.8 (1.3–3.0) | 1.6 (1.1–2.0) | NS |
| PPI | 3.8 (2.7–6.3) | 1.8 (1.5–2.1) | 0.0005 | 2.9 (2.1–4.0) | 1.7 (1.3–2.3) | 0.01 |
| EVLWI (mL/kg) | 18 (12.8–23.9) | 12.4 (7.9–16.3) | <0.0001 | 17.8 (11.2–22.8) | 12.4 (8.0–16.3) | 0.004 |
| PaO2/FiO2 ratio | 149 (75–217) | 190 (102–268) | 0.02 | 186 (128–239) | 211 (162–259) | NS |
| CXR score | 3.0 (2.0–3.0) | 2.0 (1.0–3.0) | NS | 3.0 (2.0–3.0) | 2.0 (1.0–2.0) | NS |
| Lung injury score | 2.6 (2.0–3.3) | 1.6 (1.3–2.0) | 0.006 | 2.4 (1.6–3.0) | 1.3 (1.0–2.0) | 0.02 |
| Albumin (g/L) | 0.019 (0.016–0.023) | 0.023 (0.017–0.024) | NS | 0.021 (0.018–0.022) | 0.022 (0.018–0.025) | NS |
| Platelet (109/L) | 101 (78.3–174) | 146 (74–224) | NS | 121 (75–157) | 178 (102–245) | NS |
| WBC (109/L) | 17.7 (13.1–21.9) | 16.7 (12.1–21.9) | NS | 15.4 (12.2–17.8) | 15.6 (11.2–16.5) | NS |
| SOFA score | 11 (10–13) | 6 (4–7) | 0.0001 | 10 (7–11) | 4 (2–7) | 0.0001 |
| PEEP (cm cmH2O) | 10 (8–12) | 8 (8–10) | 0.01 | 8 (6–10) | 6 (6–10) | 0.04 |
| Compliance of lung (mL/cmH2O) | 46 (37–54) | 69 (59–79) | 0.001 | 53 (40–69) | 66 (55–79) | 0.03 |
| Plateau pressure (cmH2O) | 23 (21–25) | 20 (16–22) | 0.001 | 21 (19–24) | 19 (17–22) | 0.03 |
| Mean airway pressure | 15 (14–16.7) | 14 (13–15) | 0.01 | 15 (14–16) | 14 (13–15) | NS |
| Tidal volume (mL/kg) | 5 (5–6) | 7 (6–8) | 0.001 | 6 (5–6) | 7 (6–8) | 0.02 |
| Minute ventilation (L/min) | 10.8 (10.4–12.5) | 10.2 (9.1–10.9) | 0.01 | 10.8 (9.2–12.1) | 10.5 (9.2–10.8) | NS |
| Vasopressor use | 36 (94.7) | 21 (72.4) | 0.01 | 17 (54.8) | 9 (33.3) | NS |
Definitions of abbreviation: MODS = multi-organs dysfunction syndrome; APACHE = acute physiology and chronic health evaluation; PPI, pulmonary permeability index; EVLWI = extravascular lung water index; PaO2 = partial pressure of oxygen in arterial blood; FiO2 = fraction of inspired oxygen; CXR = chest X-ray; WBC = white blood cell; SOFA = Sequential Organ Failure Assessment score; PEEP = positive end-expiratory pressure.
Values are expressed as median (interquartile range) or numbers (%).
NS = Non-significant, p>0.05.