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. 2010 Dec 16;6(12):e1001034. doi: 10.1371/journal.pcbi.1001034

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Markowetz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A A heatmap of acetylation changes between days 0 and 5 for all genes with significantly differential mRNA levels on day 5. Transcriptionally up-regulated genes show an increase in acetylation signal, while down-regulated genes show a decrease. B Visualization of the distributions of changes in acetylation signal from day 0 to day 5 for genes transcriptionally up-regulated, down-regulated or non-changing on day 5. Each plot shows four lines corresponding to the 10%, 25%, 75%, and 90% quantiles of the distributions in each bin. The hatched area emphasizes the inter-quartile range between the 25% and 75% quantile. Up-regulated genes show elevated acetylation levels close to TSS, while down-regulated genes show a broad decrease in acetylation across several kb around TSS.