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. 2010 Dec 16;6(12):e1001036. doi: 10.1371/journal.pcbi.1001036

Figure 1. Mechanism of a cell-size checkpoint involving Pom1 and Cdr2.

Figure 1

(A) Reaction network leading to the activation of mitosis in fission yeast. (B) Observed spatial distributions of Pom1 and Cdr2 in short and long cells [4], [5]. Pom1 concentration (red) is highest at the poles and lowest in the midcell region where Cdr2 concentrates in cortical nodes (green). In early interphase (short cells), Pom1 at the midcell is present at a sufficient concentration to inhibit Cdr2 and the G2/M transition via the cascade in (A). As cells grow, the midcell Pom1 concentration decreases until it crosses a threshold that relieves Cdr2 inhibition thereby promoting the G2/M transition.